High mobility group box 1 in human cancer
WebAug 12, 2024 · CAFs in human luminal breast cancer tissues with high autophagy activity enriched BCICs with increased tumourigenicity. Mechanistically, autophagic CAFs released high-mobility group box 1 (HMGB1), which activated its receptor, Toll-like receptor (TLR) 4, expressed by luminal breast cancer cells, to enhance their stemness and tumourigenicity. WebNov 7, 2013 · The high-mobility group (HMG) chromosomal proteins were discovered in mammalian cells in 1973 and named according to their high electrophoretic mobility in polyacrylamide gels ().High-mobility group box 1 (HMGB1), as a member of the HMG family, has location-specific biological functions: within the nucleus as a DNA chaper-one, within …
High mobility group box 1 in human cancer
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WebJun 30, 2014 · The High Mobility Group Box-1 (HMGB1) is a multifunction protein that serves as both a chromatin protein and an extracellular signaling molecule. ... We found … WebApr 1, 2005 · High-mobility group box 1 protein (HMGB1) is a highly conserved nuclear protein that has a surprising extracellular role. Not only does it bind DNA, increasing access to transcription factors, but ...
WebBackground: High mobility group box 1 protein (HMGB1) is known for its significant elevation in a multitude of tumors and benign diseases. In this study, we investigated the relevance of soluble HMGB1 for the prediction and monitoring of therapy response as well as the estimation of prognosis in advanced lung cancer. WebApr 4, 2024 · The role of high mobility group box-1 protein (HMGB1) in the microenvironment of non-small cell lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular and Invited Abstracts); 2024 Apr 14-19; Orlando, FL.
WebJun 21, 2024 · High Mobility Group Box 1 (HMGB1) Induces Toll-Like Receptor 4-Mediated Production of the Immunosuppressive Protein Galectin-9 in Human Cancer Cells 1 … WebFeb 25, 2013 · High mobility group box 1 (HMGB1), a non-histone DNA-binding protein, regulates nucleosome function and transcription in the nuclei of all metazoans and plants. ... Renal cell carcinoma is the most common cancer of the kidney. The main histological subtypes are clear cell (75%) ... Rocchi M and Bianchi M: The active gene that encodes …
WebHigh-mobility group-box (HMGB) domain containing proteins are also known to function in maintenance of chromosomal architecture in eukaryotes ( Antosch et al., 2012 ). In plants, HMG-box proteins are subdivided into four families: HMGB, SSRP1, ARID …
WebBackground: High mobility group box 1 (HMGB1), a versatile protein with intranuclear and extracellular functions, plays an important role in a variety of human cancers. However, … iowa city-cedar rapids areaWebJul 10, 2024 · Europe PMC is an archive of life sciences journal literature. ooh customer serviceWebApr 4, 2024 · In addition, LCD exhibited the release of danger-associated molecular patterns from cervical cancer cells, such as the release of high-mobility group box 1 (HMGB1), secretion of ATP, and exposure of calreticulin (CRT) on the cell surface, which led to immunogenic cell death (ICD). iowa city carpet cleaningWebAug 12, 2024 · CAFs in human luminal breast cancer tissues with high autophagy activity enriched BCICs with increased tumourigenicity. Mechanistically, autophagic CAFs … ooh dat baton rougeWebDec 27, 2012 · High mobility group box 1 (HMGB1) and HMGB2 overexpression has been observed in several human tumor types, and is involved in cancer progression and prognosis. However, the clinicopathological significance of HMGB1 and HMGB2 expression in bladder carcinoma (BCa), particularly the involvement of these proteins in … ooh de lally chordsWebMar 30, 2024 · Significance: As a redox-sensitive protein, high-mobility group box 1 (HMGB1) is implicated in regulating stress responses to oxidative damage and cell death, which are closely related to the pathology of inflammatory diseases, including cancer. Recent Advances: HMGB1 is a nonhistone nuclear protein that acts as a deoxyribonucleic … ooh directoryWebFeb 12, 2024 · Ke, S. et al. Downregulation of high mobility group box 1 modulates telomere homeostasis and increases the radiosensitivity of human breast cancer cells. Int J. Oncol. … iowa city cell phone