WebApr 11, 2024 · New-onset diabetes mellitus, hypokalemia, gout, skin allergy, and creatinine >150% baseline were more common among patients in HCTZ groups than placebo. Note that hyponatremia was not a reported adverse event. The incidence of serious adverse events was not higher among patients on HCTZ than placebo. WebJun 14, 2024 · In diabetic patients, insulin requirements may be increased, decreased, or unchanged due to the hydrochlorothiazide component. Diabetes mellitus that has been latent may become manifest during administration of thiazide diuretics. Because calcium excretion is decreased by thiazides, MODURETIC (amiloride and hydrochlorothiazide) …
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