WebJul 2, 2024 · Cytoplasmic dynein is a minus end-directed microtubule motor composed of 2 catalytic heavy chains and accessory subunits, including intermediate and light intermediate chains. The 2 Chlamydomonas flagellar dynein intermediate chains (ICs) have been localized to the base of the dynein complex and bind directly to the A … WebJan 4, 2005 · The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), …
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WebMar 6, 2024 · Human cytoplasmic dynein-1 (dynein) is a 1.5 MDa (1500 kDa) molecular motor that, together with its cofactor, dynactin, transports different cargoes to the minus end of the microtubules (MT) in an ATP dependent manner . Dynein is a homodimer composed of 6 different proteins: the heavy chain (HC), which acts like a scaffold where the ... WebMar 23, 2006 · The library was examined for inhibition of cytoplasmic dynein heavy chain and cell growth. The compounds showed effective antiproliferative activity against a mouse leukemia cell line but selective activities against human carcinoma cell lines. Purealin and some of the analogues inhibited the microtubule-stimulated ATPase activity of ...
WebMar 27, 2024 · Introduction. Cytoplasmic dynein 1 (dynein) is a microtubule (MT) motor protein complex that is responsible for retrograde transport of cellular cargos such as proteins, RNAs, and organelles 1, 2.Dynein is composed of four subunit classes: the heavy chain (HC), light intermediate chain (LIC), intermediate chain (IC), and light chain (LC) … WebNov 2, 2010 · Cytoplasmic dynein 2 heavy chain 1. Alternative names. Cytoplasmic dynein 2 heavy chain; Dynein cytoplasmic heavy chain 2; Dynein heavy chain 11 (hDHC11) Dynein heavy chain isotype 1B; Gene names. Name. DYNC2H1. Synonyms. DHC1B, DHC2, DNCH2, DYH1B, KIAA1997. Organism names. Organism. Homo …
WebThe \{IFT\} dynein-2 motor complex that regulates ciliary retrograde protein transport contains a heavy chain dynein ATPase/motor subunit, DYNC2H1, along with other less well functionally defined subunits. ... {WDR34\} coimmunoprecipitates with the dynein-1 light chain \{DYNLL1\} in vitro, and mining of proteomics data suggests that \{WDR34 ... WebJul 4, 2016 · DHC2 (dynein, cytoplasmic 2, heavy chain 1, also known as DYNC2H1, DHC1b, DYH1B, DNCH2, or SRTD3) belongs to a member of cytoplasmic dynein protein family and is ubiquitously expressed in cells 6.
WebTo test if this is the case in C. elegans, we generated worm strains stably coexpressing mCherry:histone H2B and GFP:fusions of cytoplasmic dynein heavy chain DHC-1 or …
WebMay 11, 2024 · Dynein Cytoplasmic 1 Heavy Chain 1 (DYNC1H1) is a protein coding gene which encodes the cytoplasmic dynein heavy chain family. This is the first … incor chattanoogaWebAug 4, 2011 · 1. Introduction. Cytoplasmic dynein is a microtubule (MT) motor protein that is involved in various activities within eukaryotic cells. Cytoplasmic dynein comprises two classes: dynein-1 and dynein-2 [1].Cytoplasmic dynein-1 is a minus-end-directed MT motor protein that moves by the energy derived from ATP hydrolysis [2], and is involved … incor constructionWebDYNC1H1, dynein cytoplasmic 1 heavy chain 1 Vertebrate Orthologs 3 Vertebrate Orthology Source. Alliance of Genome Resources. Human Ortholog DYNC1H1, dynein cytoplasmic 1 heavy chain 1. Synonyms CMT2O, DHC1, DHC1a, DNCH1, Dnchc1, DNCL, DNECL, DYHC, HL-3, p22, SMALED1 ... incisor card axieWebJan 27, 2006 · DYNC1H1, cytoplasmic dynein 1 heavy chain 1, is the largest cytoplasmic dynein subunit, having ~4,600 residues and a molecular weight of >530 kDa. First identified in rat spinal cord and brain and termed Microtubule Associated Protein 1C (MAP1C) [ 24 ], DYNC1H1 is a distant member of the AAA family of ATPases and is the … incor infrastructureWebJul 4, 2016 · Expression of dynein, cytoplasmic 2, heavy chain 1 (DHC2) associated with glioblastoma cell resistance to temozolomide Sci Rep. 2016 Jul 4; 6:28948. ... 1 Department of Neurosurgery, Nanfang Glioma Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. incisor cavityWebJun 26, 2011 · 1 Introduction. Cytoplasmic dynein is a microtubule (MT) motor protein that is involved in various activities within eukaryotic cells. Cytoplasmic dynein comprises two classes: dynein-1 and dynein-2 … incopy2022Web1 day ago · The linker position of the cytoplasmic dynein coincides with the tomographic map of the prestructure for the γ- and β-HC (Fig 4G–I). For these two HC, the linker conformation spanning over AAA2 is the same as in the Shulin–ODA. The linker for the α dynein adopts a slightly different conformation from the cytoplasmic dynein. incor-hcfmusp